Skip to main content
Figure 5 | Journal of Neuroinflammation

Figure 5

From: Inflammation early in life is a vulnerability factor for emotional behavior at adolescence and for lipopolysaccharide-induced spatial memory and neurogenesis alteration at adulthood

Figure 5

A lipopolysaccharide (LPS) challenge at adulthood impairs spatial memory in postnatal day 14 (PND14) neonatal LPS mice. Spatial memory performance was evaluated in the Y-maze test by measuring the time spent exploring the novel and the familiar arms. Measures were performed 24 h after intraperitoneal (i.p.) administration of saline or lipopolysaccharide (LPS, 100 μg/kg) in adult mice. They were assessed over a 5-min test and after a 30-min retention intertrial interval (ITI). Data are expressed as means ± SEM (n = 15/group). *P <0.05, **P <0.01, for familiar arm compared to novel arm.

Back to article page