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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring

Figure 1

High fat diet (HFD) significantly increases maternal and offspring weight. (A), Timeline for feeding schedule of HFD (60% calories from fat; black line) or control diet (CD) (10% calories from fat; white line) for the experimental conditions. (B) Percent initial weight for dams fed CD (black line, circle) or HFD (black dotted line, triangle) 6 weeks prior to and during gestation represented as mean ± SEM. N = 12 to 14 per group, *P < 0.01 (weeks 1 to 3), *P < 0.001 (week 4) or *P < 0.0001 (weeks 5 to 9), repeated measures ANOVA. (C-D) Mean weight ± SEM for male and female offspring from CD/CD, HFD/HFD, CD/HFD or HFD/CD dams at (C), P21 and (D), P32-35 (N = 7 to 22 or N = 13 to 30 per condition for males and females, respectively; one-way ANOVA with post-hoc Tukey analysis; P21 males *P = 0.0156, ****P < 0.0001; P21 females *P = 0.045, ****P < 0.0001; P32-35 males CD/CD versus HFD/HFD *P = 0.0169, CD/CD versus HFD/CD *P = 0.0319, HFD/HFD versus CD/HFD *P = 0.0113, CD/HFD versus HFD/CD *P = 0.0166; P32-35 females CD/CD versus HFD/HFD *P = 0.0189, CD/CD versus HFD/CD *P = 0.0127). Abbreviations: P, postnatal day.

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