Figure 3

Maternal high fat diet (HFD) intervention at lactation prevents social abnormalities induced in female offspring by prenatal/postnatal maternal HFD. Offspring from dams fed HFD or control diet (CD) during gestation and or lactation were examined at approximately P38-42 in the 3-chamber social assay for sociability. (A) Mean ± SEM time spent in mouse cup area - time spent in empty cup area for male and females as a measure of social interest (one-way ANOVA with post-hoc Fisher’s LSD analysis, *P = 0.029). (B) Interaction scores for sociability expressed as mean ± SEM (one-way ANOVA with post-hoc Fisher’s LSD analysis, *P = 0.0423). N = 7 to 22 or N = 13 to 30 per condition for males and females, respectively, as indicated in the graph. Abbreviations: P, postnatal day.