Figure 5

Maternal dietary intervention reduces pro-inflammatory cytokines in the central nervous system (CNS) of offspring from maternally obese dams. (A) IL-1Β and (B) TNFΑ protein levels in brains from male or female offspring were examined at six weeks of age by ELISA. Values are depicted as mean ± SEM with N = 4 to 7 for males and N = 5 to 12 per condition for females as indicated in the graph. One-way ANOVA with post-hoc Tukey analysis, female IL-1Β CD/CD versus HFD/HFD *P = 0.0385; female TNFΑ CD/CD versus HFD/HFD *P = 0.0106, HFD/HFD versus CD/HFD *P = 0.0182, HFD/HFD versus HFD/CD **P = 0.0008. No significant differences were found in male offspring. Abbreviations: CD, control diet; HFD, high fat diet; P, postnatal day.