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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Calcineurin and glial signaling: neuroinflammation and beyond

Figure 3

CN dephosphorylates Cx43 and modulates GJ coupling in astrocytes. (A) Cx hexamers on the astrocyte membrane form GJ channels with apposing Cx hexamers in adjacent cells and allow the intercellular passage of small molecules like Ca2+ and IP3. (B) Activation of astrocytes with inflammatory mediators stimulates CN, which dephosphorylates the cytoplasmic tail of Cx43. Dephosphorylation of Cx43 is associated with reduced GJ coupling, though it is unclear whether dephosphorylation is a cause or consequence of decoupling.

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