Figure 3

Confocal imaging showing that TIB67 macrophages are more efficient in phagocytosis of tau oligomers than BV2 microglia. Confocal cross-section analyses of cells show a higher number of tau oligomers engulfed by macrophages than by BV2 microglial cells. Micrographs show tau oligomers positive TIB67 macrophages non-treated (A) or treated with LPS (B). Cross-sections show that tau is internalized within the cells. Tau oligomer positive BV2 cells without and with LPS stimulation are shown in panels (C) and (D), respectively. LPS-stimulated microglia contain tau oligomers internalized, while non-stimulated cells have tau particles rather attached to the outside of the cells. Scale bar: 20 μM. Abbreviation: μM, micrometer.