Figure 4

Immunofluorescent study reveals a higher efficacy of peripheral blood-derived monocytes to phagocytose tau oligomers than primary microglia. The panels show quantification data of PB-MoM macrophages (A) and primary microglia (B) engulfing oligomerized beads in the presence or absence of LPS treatment. (C) Quantitative comparison of PB-MoM macrophages and primary microglia phagocytic efficacy of beads oligomers after 24 hours. Quantification of PB-MoM macrophages (D) and primary microglia (E) phagocytosing tau oligomers in the presence or absence of LPS treatment. (F) Quantitative comparison of PB-MoM macrophages and primary microglia and primary microglia cells phagocytosis of tau oligomers after 24 hours. The experiments were run in triplicates. Data are presented as mean ± standard error of the mean (SEM). Statistical significance was defined as P <0.05 (*) or P <0.01 (**). Abbreviations: SEM, standard error of the mean; P, p-value; PB-MoM, Peripheral blood monocyte-derived macrophages.