Macrophages and microglia can degrade tau oligomers. Western blot analyses of extracts from TIB67 macrophages (A), BV2 microglia (B), peripheral blood monocyte-derived macrophages (C) and primary microglia (D) challenged with oligomerized (misfolded) tau for 2, 6 and 24 hours showed that macrophages are more potent in degradation of tau oligomers than microglia. Microglia were able to phagocytose and degrade tau oligomers only after LPS stimulation. Western blots were developed with DC25 antibody. w/o, without. Abbreviations: w/o, without; LPS, lipopolysaccharide.