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Figure 8 | Journal of Neuroinflammation

Figure 8

From: Diet-induced obesity and low testosterone increase neuroinflammation and impair neural function

Figure 8

Low testosterone and high-fat diet promote hyperalgesia and Na + ,K + -ATPase activity in sciatic nerve. (A) Quantitative graph shows the mean (±SEM) temperature threshold for sham GDX (Sham), GDX, and GDX mice with testosterone treatment (GDX + T) in both control-diet and high-fat diet fed mice. (B) Quantitative graph show the mean (±SEM) latency to thermal nociception (at 50°C) in different animal groups. (C) Quantitative graph shows the mean (±SEM) activity levels of Na+,K+-ATPase in the sciatic nerve of animals in the different treatment groups. Statistical significance is based on ANOVA followed by Bonferroni. * P ≤0.05 between diet groups; ** P ≤0.05 between hormone groups; N ≥6.

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