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Table 2 Genes significantly more strongly regulated by the capsule-deficient mutant strain MC58siaD - compared with MC58 and the carrier isolate α14 as well as genes identified to be significantly more strongly regulated comparing expression levels of cells infected with MC58 and the carrier isolate α14 with FC ≥1.5 FC ≤0.67 and a corresponding P value ≤0.001

From: Neisseria meningitidiselicits a pro-inflammatory response involving IκBζ in a human blood-cerebrospinal fluid barrier model

UniGene_ID

Gene title

Gene symbol

Fold change

   

MC58siaD-vs. MC58

MC58siaD-vs. α14

MC58 vs. α14

Hs.75765

chemokine (C-X-C motif) ligand 2

CXCL2

2.25

4.03

1.79

Hs.75498

chemokine (C-C motif) ligand 20

CCL20

2.33

3.45

 

Hs.89690

chemokine (C-X-C motif) ligand 3

CXCL3

1.94

3.28

1.69

Hs.319171

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta

NFKBIZ

1.77

3.01

1.70

Hs.624

interleukin 8

IL8

1.77

2.51

 

Hs.196384

prostaglandin-endoperoxide synthase (prostaglandin G/H synthase and cyclooxygenase)

PTGS2

1.99

2.47

 

Hs.643447

intercellular adhesion molecule 1

ICAM1

1.80

2.35

 

Hs.211600

tumor necrosis factor, alpha-induced protein 3

TNFAIP3

1.61

2.16

 

Hs.81328

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

NFKBIA

1.55

2.14

 

Hs.241570

tumor necrosis factor (TNF superfamily, member 2)

TNF

1.54

2.14

 

Hs.376208

Lymphotoxin beta (TNF superfamily, member 3)

LTB

1.70

2.13

 

Hs.164021

chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)

CXCL6

1.92

2.08

 

Hs.77274

plasminogen activator, urokinase

PLAU

1.70

1.98

 

Hs.656294

zinc finger CCCH-type containing 12A

ZC3H12A

 

1.93

 

Hs.432132

G0/G1switch 2

G0S2

1.56

1.86

 

Hs.522109

solute carrier family 6 (amino acid transporter), member 14

SLC6A14

1.52

1.73

 

Hs.525607

tumor necrosis factor, alpha-induced protein 2

TNFAIP2

 

1.67

 

Hs.436061

interferon regulatory factor 1

IRF1

 

1.63

 

Hs.591849

chromosome 8 open reading frame 4

C8orf4

 

1.62

 

Hs.515415

inositol 1,4,5-trisphosphate 3-kinase C

ITPKC

 

1.62

 

Hs.127799

baculoviral IAP repeat-containing 3

BIRC3

 

1.61

 

Hs.124940

Rho family GTPase 1

RND1

 

1.60

 

Hs. 98309

interleukin 23, alpha subunit p19

IL23A

 

1.56

 

Hs.115263

epiregulin

EREG

 

1.55

 

Hs.632267

syndecan 4

SDC4

 

1.55

 

Hs.656630

230333_at

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1.53

 
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Journal of Neuroinflammation

ISSN: 1742-2094