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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation

Figure 1

Chemical structure of bilobalide and experimental protocol. (A) Rat MCAO/R and in vitro OGD/R model of cerebral ischemia and reperfusion injury. Bilobalide (2.5, 5, and 10 mg/kg) was administered via a single intraperitoneal injection 60 min prior to surgery in the rat model. In the cell model, cortical neurons were previously cultured in bilobalide (50, 100 μM) for 12 h by dissolving bilobalide in serum-free DMEM. (B) Experimental protocol; neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with pro-inflammatory mediator production and MAPK signaling pathway. (C) Chemical structure of bilobalide. BB, bilobalide; MCAO/R, middle cerebral artery occlusion and reperfusion; MDA, malondialdehyde; OGD/R, oxygen-glucose deprivation and reoxygenation; SOD, superoxide dismutase; TTC, 2,3,5-triphenyltetrazolium chloride.

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Journal of Neuroinflammation

ISSN: 1742-2094