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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation

Figure 2

Effects of bilobalide on neurological deficit scores, infarct volume, and infarct weight. (A) Representative photographs of brain slices following infarction, stained with 2, 3, 5-triphenyltetrazolium chloride. Red tissue is healthy; white tissue is infarcted. Pretreatment with bilobalide (5, 10 mg/kg) significantly reduced infarct size (B) and improved neurological scores (C) and decreased infarct volume and infarct weight compared with the MCAO/R group. Mean values ± standard error of the mean for 15 (neurological evaluation) and six rats per group. ** P < 0.01 versus sham; ## P < 0.01 versus MCAO/R. BB, bilobalide; MCAO/R, middle cerebral artery occlusion and reperfusion; NMP, nimodipine.

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Journal of Neuroinflammation

ISSN: 1742-2094