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Figure 7 | Journal of Neuroinflammation

Figure 7

From: Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation

Figure 7

Effects of bilobalide on cell viability in primary cortical neurons after OGD/R. (A) Incubation of cortical neurons with different concentrations of bilobalide (50, 100 μM) alone for 12 h did not affect cell viability. After cortical neurons were exposed to 2 h of OGD following 24 h of reoxygenation, cell viability was significantly decreased; pretreatment with bilobalide (50, 100 μM) for 12 h significantly the cell viability. (B) After cortical neurons were exposed to 2 h of OGD following 24 h of reoxygenation, the level of LDH release was remarkably increased; pretreatment with bilobalide (50, 100 μM) for 12 h significantly decreased the LDH level. Mean values ± standard error of the mean ** P < 0.01 versus control; # P < 0.05, ## P < 0.01 versus. OGD/R. BB, bilobalide; LDH, lactate dehydrogenase; OGD/R, oxygen-glucose deprivation and reoxygenation.

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