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Table 2 Correlation of kynurenine to tryptophan (KYN/TRP) ratio and KYN metabolites with cerebrospinal fluid (CSF) cytokine levels in patients with bacterial meningitis (BM)

From: The kynurenine pathway is involved in bacterial meningitis

 

IFN-γ

TNF-α

IL-10

IL-1RA

KYN/TRP ratio

0.77

-

-

0.63

KYN

-

0.77

-

-

KYNA

-

-

0.57

-

P-value

P < 0.01

P < 0.01

P < 0.05

P < 0.05

  1. -Values mean the results obtained from Spearman’s correlation. Data did not follow Gaussian distribution. Abbreviation: KYNA kynurenic acid.