Figure 2
Different immune responses in cerebrospinal fluid (CSF) of patients with rapidly progressive dementia. (A-B) Profiling of cytokines (pg/ml) in CSF from Creutzfeldt-Jakob disease (CJD) (n =12), multiple sclerosis (MS) (n =12), Alzheimer’s disease (AD) (n =20), a rapidly progressive form of AD (rpAD) (n =15) and control (n =12) patients was performed by using the Bio-Plex Pro human cytokine 17-plex assay. A significant increase of IL-8 was found in CJD patients, while the level of MCP-1 was significantly elevated in CJD and AD patients but not in rpAD patients compared to control donors. (C) PrPC level in the CSF did not vary significantly among groups (n =12). Columns represent means with SD. Statistics were performed by using the non-parametric Kruskal-Wallis test (+ Turkey's post hoc tests). The number of stars indicates the significance level: one star (*) for P <0.05, two (**) for P <0.01 and three (***) for P <0.001.