Figure 2

MRL/lpr ERαKO mice perform better than MRL/lpr WT in WRAM testing. (A) Reference memory learning curve. The one-within (session) repeated measures revealed a significant effect of sessions for days 1 to 12. (B) In the late or asymptotic phase (days 10 to 12), MRL/lpr ERαKO mice outperformed MRL/lpr mice, with significantly fewer reference memory errors made. (C, D) Average errors made in the late or asymptotic phase (days 10 to 12) revealed that MRL/lpr ERαKO mice made significantly fewer errors than MRL/lpr mice in both working memory incorrect and working memory correct errors.