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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Molecular profile of cochlear immunity in the resident cells of the organ of Corti

Figure 2

Typical images of immune cell distribution in the cochlea. (A) Distribution of immune cells, which were marked by CD45 immunolabeling (green fluorescence marked by arrows) in a whole mount preparation of the cochlea. The tissue was doubly labeled with propidium iodide (red fluorescence), a nuclear dye, to illustrate the tissue structure. Immune cells are present in the lateral wall, the sensory epithelium and the spiral osseous lamina. (B) Typical images showing the location of immune cells in the region of the sensory epithelium. Top panel: a surface view of the basilar membrane. The immune cells labeled with CD45 (red fluorescence) reside alongside spindle-shaped mesothelial cells. The arrow points to an immune cell. The middle panel: a side view of the basilar membrane presented in the top panel. The bottom panel: a schematic drawing of the middle panel image. The arrow points to the immune cell illustrated also in the middle panel. Note that this immune cell is located in the scala tympani side of the basilar membrane.

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