Figure 6
From: Molecular profile of cochlear immunity in the resident cells of the organ of Corti
Maintenance of auditory function in Tlr4 knockout mice. (A) Comparison of the ABR thresholds between Tlr4 knockout mice and wild-type mice at four tested frequencies. There is no significant difference in the thresholds between the 2 types of mice (2-way ANOVA, P >0.05), indicating that disruption of the Tlr4 signaling pathway does not affect auditory function. (B) Transcriptional expression levels of Tlr4 in the organ of Corti of Tlr4 knockout and wild-type mice examined by qRT-PCR. The average expression levels of three reference genes (Hprt1, Hsp90ab1, Rpl13a) in the same samples are also present. The expression of Tlr4 was not detected in the Tlr4 knockout mice. This observation confirms that the knockout mice lack Tlr4 expression.