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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Microglial activation occurs in the absence of anxiety-like behavior following microembolic stroke in female, but not male, rats

Figure 1

Male and female sham and microsphere embolism (ME) rats were run in a 5-minute elevated plus maze. (A) Total distance traveled of male and female sham and ME rats indicated a significant effect of sex, such that female rats traveled more overall as compared to male rats (P <0.05). (B) A significant interaction between sex and surgery was detected in the elevated plus maze: specifically, compared to male sham, male ME rats spent less time in the open arms of the elevated plus maze, indicative of an anxiety-like state. No difference was detected between female sham and ME rats (P <0.05). (C) Similarly, the number of stretch attend postures were significantly higher in male ME rats compared to both sham and female rats (P <0.05). For all, error bars represent standard error of the mean (SEM) and *indicates P <0.05.

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Journal of Neuroinflammation

ISSN: 1742-2094