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Figure 3 | Journal of Neuroinflammation

Figure 3

From: The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism

Figure 3

p38α ΔLysM-Cre knockout (KO) mice show no suppression of the proinflammatory cytokine response to intracerebroventricular (ICV) injection of lipopolysaccharide (LPS). At 6 hr post-ICV injection, levels of cytokines were measured in the ipsilateral hippocampus (A) and serum (B) of wild-type (WT) mice (white) or p38αΔLysM-Cre KO mice administered saline (vehicle (veh): gray) or 25 ng LPS (black). (n = 4 per veh group (WT = 2, KO = 2); n = 8 per LPS group) (*P <0.05).

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