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Figure 5 | Journal of Neuroinflammation

Figure 5

From: The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism

Figure 5

Levels of anti-inflammatory cytokines in the serum and cortex of mice following systemic lipopolysaccharide (LPS) stimulation. Wild-type (WT) mice (white) or p38αΔLysM-Cre knockout (KO) mice (black) were injected intraperitoneally (IP) with 5 mg/kg LPS. No significant differences in IL-1ra levels in serum (A) or CNS (B) were detected between WT and p38αΔLysM-Cre KO mice. Levels of IL-10 in the serum were significantly reduced in the p38αΔLysM-Cre KO mice (A), and there was a trend for reduced levels of IL-10 in the CNS (B) although the data did not reach statistical significance (n =5 to 8 per group) (**P <0.01; ***P <0.001).

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