TY - JOUR AU - Mathers, C. D. AU - Boerma, T. AU - Ma Fat, D. PY - 2009 DA - 2009// TI - Global and regional causes of death JO - Br Med Bull VL - 92 UR - https://doi.org/10.1093/bmb/ldp028 DO - 10.1093/bmb/ldp028 ID - Mathers2009 ER - TY - JOUR AU - Kleindorfer, D. AU - Lindsell, C. J. AU - Brass, L. AU - Koroshetz, W. AU - Broderick, J. P. PY - 2008 DA - 2008// TI - National US estimates of recombinant tissue plasminogen activator use: ICD-9 codes substantially underestimate JO - Stroke VL - 39 UR - https://doi.org/10.1161/STROKEAHA.107.490375 DO - 10.1161/STROKEAHA.107.490375 ID - Kleindorfer2008 ER - TY - JOUR AU - Martin-Montalvo, A. AU - Mercken, E. M. AU - Mitchell, S. J. AU - Palacios, H. H. AU - Mote, P. L. AU - Scheibye-Knudsen, M. AU - Gomes, A. P. AU - Ward, T. M. AU - Minor, R. K. AU - Blouin, M. J. AU - Schwab, M. AU - Pollak, M. AU - Zhang, Y. AU - Yu, Y. AU - Becker, K. G. AU - Bohr, V. A. AU - Ingram, D. K. AU - Sinclair, D. A. AU - Wolf, N. S. AU - Spindler, S. R. AU - Bernier, M. AU - de Cabo, R. PY - 2013 DA - 2013// TI - Metformin improves healthspan and lifespan in mice JO - Nat Commun VL - 4 UR - https://doi.org/10.1038/ncomms3192 DO - 10.1038/ncomms3192 ID - Martin-Montalvo2013 ER - TY - JOUR AU - Calvert, J. W. AU - Gundewar, S. AU - Jha, S. AU - Greer, J. J. AU - Bestermann, W. H. AU - Tian, R. AU - Lefer, D. J. PY - 2008 DA - 2008// TI - Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling JO - Diabetes VL - 57 UR - https://doi.org/10.2337/db07-1098 DO - 10.2337/db07-1098 ID - Calvert2008 ER - TY - STD TI - Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998, 352: 854-865. 10.1016/S0140-6736(98)07037-8. ID - ref5 ER - TY - JOUR AU - Diamanti-Kandarakis, E. AU - Paterakis, T. AU - Alexandraki, K. AU - Piperi, C. AU - Aessopos, A. AU - Katsikis, I. AU - Katsilambros, N. AU - Kreatsas, G. AU - Panidis, D. PY - 2006 DA - 2006// TI - Indices of low-grade chronic inflammation in polycystic ovary syndrome and the beneficial effect of metformin JO - Hum Reprod VL - 21 UR - https://doi.org/10.1093/humrep/del003 DO - 10.1093/humrep/del003 ID - Diamanti-Kandarakis2006 ER - TY - JOUR AU - Mihaylova, M. M. AU - Shaw, R. J. PY - 2011 DA - 2011// TI - The AMPK signalling pathway coordinates cell growth, autophagy and metabolism JO - Nat Cell Biol VL - 13 UR - https://doi.org/10.1038/ncb2329 DO - 10.1038/ncb2329 ID - Mihaylova2011 ER - TY - JOUR AU - Dasgupta, B. AU - Milbrandt, J. PY - 2007 DA - 2007// TI - Resveratrol stimulates AMP kinase activity in neurons JO - Proc Natl Acad Sci U S A VL - 104 UR - https://doi.org/10.1073/pnas.0610068104 DO - 10.1073/pnas.0610068104 ID - Dasgupta2007 ER - TY - JOUR AU - Davis, B. J. AU - Xie, Z. AU - Viollet, B. AU - Zou, M. H. PY - 2006 DA - 2006// TI - Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase JO - Diabetes VL - 55 UR - https://doi.org/10.2337/diabetes.55.02.06.db05-1064 DO - 10.2337/diabetes.55.02.06.db05-1064 ID - Davis2006 ER - TY - JOUR AU - Sasaki, H. AU - Asanuma, H. AU - Fujita, M. AU - Takahama, H. AU - Wakeno, M. AU - Ito, S. AU - Ogai, A. AU - Asakura, M. AU - Kim, J. AU - Minamino, T. AU - Takashima, S. AU - Sanada, S. AU - Sugimachi, M. AU - Komamura, K. AU - Mochizuki, N. AU - Kitakaze, M. PY - 2009 DA - 2009// TI - Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase JO - Circulation VL - 119 UR - https://doi.org/10.1161/CIRCULATIONAHA.108.798561 DO - 10.1161/CIRCULATIONAHA.108.798561 ID - Sasaki2009 ER - TY - JOUR AU - Spasic, M. R. AU - Callaerts, P. AU - Norga, K. K. PY - 2009 DA - 2009// TI - AMP-activated protein kinase (AMPK) molecular crossroad for metabolic control and survival of neurons JO - Neuroscientist VL - 15 UR - https://doi.org/10.1177/1073858408327805 DO - 10.1177/1073858408327805 ID - Spasic2009 ER - TY - JOUR AU - Hattori, Y. AU - Suzuki, K. AU - Hattori, S. AU - Kasai, K. PY - 2006 DA - 2006// TI - Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells JO - Hypertension VL - 47 UR - https://doi.org/10.1161/01.HYP.0000221429.94591.72 DO - 10.1161/01.HYP.0000221429.94591.72 ID - Hattori2006 ER - TY - JOUR AU - O'Neill, L. A. AU - Hardie, D. G. PY - 2013 DA - 2013// TI - Metabolism of inflammation limited by AMPK and pseudo-starvation JO - Nature VL - 493 UR - https://doi.org/10.1038/nature11862 DO - 10.1038/nature11862 ID - O'Neill2013 ER - TY - JOUR AU - Choi, J. S. AU - Park, J. AU - Suk, K. AU - Moon, C. AU - Park, Y. K. AU - Han, H. S. PY - 2011 DA - 2011// TI - Mild Hypothermia Attenuates Intercellular Adhesion Molecule-1 Induction via Activation of Extracellular Signal-Regulated Kinase-1/2 in a Focal Cerebral Ischemia Model JO - Stroke Res Treat VL - 2011 ID - Choi2011 ER - TY - JOUR AU - Chopp, M. AU - Li, Y. AU - Jiang, N. AU - Zhang, R. L. AU - Prostak, J. PY - 1996 DA - 1996// TI - Antibodies against adhesion molecules reduce apoptosis after transient middle cerebral artery occlusion in rat brain JO - J Cereb Blood Flow Metab VL - 16 UR - https://doi.org/10.1097/00004647-199607000-00007 DO - 10.1097/00004647-199607000-00007 ID - Chopp1996 ER - TY - JOUR AU - Greenwood, J. AU - Mason, J. C. PY - 2007 DA - 2007// TI - Statins and the vascular endothelial inflammatory response JO - Trends Immunol VL - 28 UR - https://doi.org/10.1016/j.it.2006.12.003 DO - 10.1016/j.it.2006.12.003 ID - Greenwood2007 ER - TY - JOUR AU - Strecker, J. K. AU - Sevimli, S. AU - Schilling, M. AU - Klocke, R. AU - Nikol, S. AU - Schneider, A. AU - Schabitz, W. R. PY - 2010 DA - 2010// TI - Effects of G-CSF treatment on neutrophil mobilization and neurological outcome after transient focal ischemia JO - Exp Neurol VL - 222 UR - https://doi.org/10.1016/j.expneurol.2009.12.012 DO - 10.1016/j.expneurol.2009.12.012 ID - Strecker2010 ER - TY - JOUR AU - Yenari, M. A. AU - Han, H. S. PY - 2012 DA - 2012// TI - Neuroprotective mechanisms of hypothermia in brain ischaemia JO - Nat Rev Neurosci VL - 13 ID - Yenari2012 ER - TY - JOUR AU - Wasserman, J. K. AU - Schlichter, L. C. PY - 2007 DA - 2007// TI - Minocycline protects the blood-brain barrier and reduces edema following intracerebral hemorrhage in the rat JO - Exp Neurol VL - 207 UR - https://doi.org/10.1016/j.expneurol.2007.06.025 DO - 10.1016/j.expneurol.2007.06.025 ID - Wasserman2007 ER - TY - JOUR AU - Wang, J. AU - Gallagher, D. AU - DeVito, L. M. AU - Cancino, G. I. AU - Tsui, D. AU - He, L. AU - Keller, G. M. AU - Frankland, P. W. AU - Kaplan, D. R. AU - Miller, F. D. PY - 2012 DA - 2012// TI - Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation JO - Cell Stem Cell VL - 11 UR - https://doi.org/10.1016/j.stem.2012.03.016 DO - 10.1016/j.stem.2012.03.016 ID - Wang2012 ER - TY - JOUR AU - He, X. AU - Li, Y. AU - Lu, H. AU - Zhang, Z. AU - Wang, Y. AU - Yang, G. Y. PY - 2013 DA - 2013// TI - Netrin-1 overexpression promotes white matter repairing and remodeling after focal cerebral ischemia in mice JO - J Cereb Blood Flow Metab VL - 33 UR - https://doi.org/10.1038/jcbfm.2013.150 DO - 10.1038/jcbfm.2013.150 ID - He2013 ER - TY - JOUR AU - Liu, Y. AU - Tang, G. H. AU - Sun, Y. H. AU - Lin, X. J. AU - Wei, C. AU - Yang, G. Y. AU - Liu, J. R. PY - 2013 DA - 2013// TI - The protective role of Tongxinluo on blood-brain barrier after ischemia-reperfusion brain injury JO - J Ethnopharmacol VL - 148 UR - https://doi.org/10.1016/j.jep.2013.05.018 DO - 10.1016/j.jep.2013.05.018 ID - Liu2013 ER - TY - JOUR AU - Huang, J. AU - Li, Y. AU - Tang, Y. AU - Tang, G. AU - Yang, G. Y. AU - Wang, Y. PY - 2013 DA - 2013// TI - CXCR4 antagonist AMD3100 protects blood-brain barrier integrity and reduces inflammatory response after focal ischemia in mice JO - Stroke VL - 44 UR - https://doi.org/10.1161/STROKEAHA.112.670299 DO - 10.1161/STROKEAHA.112.670299 ID - Huang2013 ER - TY - JOUR AU - Takata, F. AU - Dohgu, S. AU - Matsumoto, J. AU - Machida, T. AU - Kaneshima, S. AU - Matsuo, M. AU - Sakaguchi, S. AU - Takeshige, Y. AU - Yamauchi, A. AU - Kataoka, Y. PY - 2013 DA - 2013// TI - Metformin induces up-regulation of blood-brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells JO - Biochem Biophys Res Commun VL - 433 UR - https://doi.org/10.1016/j.bbrc.2013.03.036 DO - 10.1016/j.bbrc.2013.03.036 ID - Takata2013 ER - TY - JOUR AU - Force, I. C. G. T. PY - 2006 DA - 2006// TI - Global Guideline for Type 2 Diabetes: recommendations for standard, comprehensive, and minimal care JO - Diabet Med VL - 23 UR - https://doi.org/10.1111/j.1464-5491.2006.01918.x DO - 10.1111/j.1464-5491.2006.01918.x ID - Force2006 ER - TY - JOUR AU - Li, J. AU - Benashski, S. E. AU - Venna, V. R. AU - McCullough, L. D. PY - 2010 DA - 2010// TI - Effects of metformin in experimental stroke JO - Stroke VL - 41 UR - https://doi.org/10.1161/STROKEAHA.110.589697 DO - 10.1161/STROKEAHA.110.589697 ID - Li2010 ER - TY - JOUR AU - Harada, S. AU - Fujita-Hamabe, W. AU - Tokuyama, S. PY - 2010 DA - 2010// TI - The importance of regulation of blood glucose levels through activation of peripheral 5'-AMP-activated protein kinase on ischemic neuronal damage JO - Brain Res VL - 1351 UR - https://doi.org/10.1016/j.brainres.2010.06.052 DO - 10.1016/j.brainres.2010.06.052 ID - Harada2010 ER - TY - JOUR AU - Li, W. AU - Qu, Z. AU - Prakash, R. AU - Chung, C. AU - Ma, H. AU - Hoda, M. N. AU - Fagan, S. C. AU - Ergul, A. PY - 2013 DA - 2013// TI - Comparative analysis of the neurovascular injury and functional outcomes in experimental stroke models in diabetic Goto-Kakizaki rats JO - Brain Res VL - 1541 UR - https://doi.org/10.1016/j.brainres.2013.10.021 DO - 10.1016/j.brainres.2013.10.021 ID - Li2013 ER - TY - JOUR AU - Gidday, J. M. PY - 2006 DA - 2006// TI - Cerebral preconditioning and ischaemic tolerance JO - Nat Rev Neurosci VL - 7 UR - https://doi.org/10.1038/nrn1927 DO - 10.1038/nrn1927 ID - Gidday2006 ER - TY - JOUR AU - Shibata, R. AU - Sato, K. AU - Pimentel, D. R. AU - Takemura, Y. AU - Kihara, S. AU - Ohashi, K. AU - Funahashi, T. AU - Ouchi, N. AU - Walsh, K. PY - 2005 DA - 2005// TI - Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms JO - Nat Med VL - 11 UR - https://doi.org/10.1038/nm1295 DO - 10.1038/nm1295 ID - Shibata2005 ER - TY - JOUR AU - Nishimura, M. AU - Izumiya, Y. AU - Higuchi, A. AU - Shibata, R. AU - Qiu, J. AU - Kudo, C. AU - Shin, H. K. AU - Moskowitz, M. A. AU - Ouchi, N. PY - 2008 DA - 2008// TI - Adiponectin prevents cerebral ischemic injury through endothelial nitric oxide synthase dependent mechanisms JO - Circulation VL - 117 UR - https://doi.org/10.1161/CIRCULATIONAHA.107.725044 DO - 10.1161/CIRCULATIONAHA.107.725044 ID - Nishimura2008 ER - TY - JOUR AU - Salminen, A. AU - Kaarniranta, K. PY - 2012 DA - 2012// TI - AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network JO - Ageing Res Rev VL - 11 UR - https://doi.org/10.1016/j.arr.2011.12.005 DO - 10.1016/j.arr.2011.12.005 ID - Salminen2012 ER - TY - JOUR AU - Tak, P. P. AU - Firestein, G. S. PY - 2001 DA - 2001// TI - NF-kappaB: a key role in inflammatory diseases JO - J Clin Invest VL - 107 UR - https://doi.org/10.1172/JCI11830 DO - 10.1172/JCI11830 ID - Tak2001 ER - TY - JOUR AU - Isoda, K. AU - Young, J. L. AU - Zirlik, A. AU - MacFarlane, L. A. AU - Tsuboi, N. AU - Gerdes, N. AU - Schonbeck, U. AU - Libby, P. PY - 2006 DA - 2006// TI - Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells JO - Arterioscler Thromb Vasc Biol VL - 26 UR - https://doi.org/10.1161/01.ATV.0000201938.78044.75 DO - 10.1161/01.ATV.0000201938.78044.75 ID - Isoda2006 ER - TY - JOUR AU - Chopp, M. AU - Zhang, Z. G. AU - Jiang, Q. PY - 2007 DA - 2007// TI - Neurogenesis, angiogenesis, and MRI indices of functional recovery from stroke JO - Stroke VL - 38 UR - https://doi.org/10.1161/01.STR.0000250235.80253.e9 DO - 10.1161/01.STR.0000250235.80253.e9 ID - Chopp2007 ER - TY - JOUR AU - Potts, M. B. AU - Lim, D. A. PY - 2012 DA - 2012// TI - An old drug for new ideas: metformin promotes adult neurogenesis and spatial memory formation JO - Cell Stem Cell VL - 11 UR - https://doi.org/10.1016/j.stem.2012.06.003 DO - 10.1016/j.stem.2012.06.003 ID - Potts2012 ER -