Figure 2
Viral pre-challenge increases the acute mobilisation of neutrophils in response to the microinjection of IL-1β into the brain. Neutrophils immunohistochemically assessed in (A) whole blood and (B) liver 12 hours, 3 days or 7 days following IL-1Β challenge to the brain in the presence of intravenous vehicle (solid line) or AdLuc (5 × 109 CFU - dashed line). Dotted line represents animals microinjected with saline into the brain, in the presence of intravenous AdLuc. Intravenous injections are indicated by italic text. Results are expressed as mean ± SEM (n =3), ***P <0.001. CFU, colony-forming unit.