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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Validation of semaphorin 7A and ala-β-his-dipeptidase as biomarkers associated with the conversion from clinically isolated syndrome to multiple sclerosis

Figure 1

CSF levels of apolipoprotein AI, apolipoprotein AIV, vitronectin, plasminogen, semaphorin 7A, and ala-beta-his-dipeptidase in a first and partially independent cohort of MS converters and non-converters. (A) Boxplots showing CSF levels of apolipoprotein AI, apolipoprotein AIV, vitronectin, and plasminogen determined by commercially available ELISAs. (B) Boxplots representing CSF abundance of CNDP1 and semaphorin 7A determined by selected reaction monitoring. Statistically significant P values are shown in bold. *Indicates that significant differences were also observed between CIS → CDMS and controls (P = 3.3× 10-14 for semaphorin 7A and P = 3.6 ± 10-9 for ala-beta-his dipeptidase). CIS → CIS: CIS patients who did not convert to clinically definite MS during the follow-up period. CIS → CDMS: CIS patients who converted to clinically definite MS. C: controls with other neurological disorders. Numbers in parentheses indicate individuals available for analysis. CDMS, clinically definite multiple sclerosis; CDNP1, ala-beta-his-dipeptidase; CIS, clinically isolated syndromes, CSF, cerebrospinal fluid.

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