Activation of glycerophospholipid metabolism in response to IL-6. (A) Numerous glycerophospholipid metabolites were significantly produced upon IL-6 exposure in both astrocytes and neuronal cultures. Three analytes were putatively identified as diacylglycerophosphocholine (m/z 732.55, ALR = 1.57, P <0.001), diacylglycerophospho-ethanolamine (m/z 768.56, ALR = 1.39, P <0.001), and n-methylethanolamine (m/z 156.04, ALR = 1.81, P <0 .001). Putative identifications were obtained by using mass measurement accuracy, retention time and confirmed based on fragmentation spectra [see Additional files 1, 2, 3, 4 and 5]. (B) Illustrates a simplified glycerophospholipid metabolism pathway and shows that n-methylethanolamine is a precursor metabolite to numerous developmentally important downstream metabolites.