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Table 5 IL-6 production by purified peripheral blood monocytes in the study groups

From: Cytokine profiles by peripheral blood monocytes are associated with changes in behavioral symptoms following immune insults in a subset of ASD subjects: an inflammatory subtype?

Study group Without stimuli [pg/ml] LPS Zymosan
ASD-IS    
- Flare 4541.7 ± 1332.8a 20662 ± 6181 936.6 ± 575.1b
- Non-Flare 3136.6 ± 1276.7 19420 ± 7051 1235.4 ± 1217
ASD/NFA 3682.7 ± 1613.3 17708 ± 10952 1352.4 ± 831.6
ASD/non-NFA 3827.3 ± 1467.4 18632 ± 10615 1281.7 ± 1068.5
Non-ASD/NFA 4029.8 ± 1246.1 20040 ± 6837 1334.0 ± 1031.4
Normal control 3102.8 ± 1225.4 17919 ± 10845 1716.1 ± 942.7
PANS    
- Flare 4005.0 ± 1512.2 22455 ± 9097 1123.9 ± 1487.5
- Non-Flare 3726.9 ± 1143.0 19663 ± 9718 871.6 ± 1013.0
  1. aSpontaneous IL-6 production by `flare’ ASD-IS cells was higher than `non-flare’ cells in matched pair analysis, as shown in Figure 4 and also higher than those produced by ASD/NFA and normal control cells.
  2. bIL-6 production by `flare’ ASD-IS cells in response to zymosan was lower than those produced by normal control cells (P <0.02) and also lower than the `non-flare’ ASD-IS cells in matched pair analysis (P <0.01).
  3. c Abbreviations used; ASD, autism spectrum disorder; ASD-IS, ASD-inflammatory subtype; IL, interleukin; LPS, lipopolysaccharide; NFA, non-IgE mediated food allergy; PANS, pediatric acute-onset neuropsychiatric syndrome.