Skip to main content
Figure 1 | Journal of Neuroinflammation

Figure 1

From: Epstein-Barr virus-specific intrathecal oligoclonal IgG production in relapsing-remitting multiple sclerosis is limited to a subset of patients and is composed of low-affinity antibodies

Figure 1

Oligoclonal band profiles. A comparison between total (A) and Epstein-Barr virus (EBV)-specific (B) IgG oligoclonal band (OCB) profiles obtained with isoelectric focusing (IEF) and antigen-specific immunoblotting, respectively, in paired cerebrospinal fluid (CSF) and serum samples of two relapsing-remitting multiple sclerosis (RRMS) patients. Corresponding bands are indicated by arrows. Among the RRMS patients with EBV-specific IgG OCB, CSF-restricted total IgG OCB were absent only in an RRMS patient with a `mirror’ pattern. In the remaining 24 RRMS patients with an EBV-specific intrathecal oligoclonal IgG synthesis, there was little overlap between total and virus-specific IgG OCB unique to CSF due to their high individual variability. More precisely, the EBV-specific OCB numbered fewer (mean ± SD = 3.6 ± 1.9; range from 2 to 9) than total IgG OCB (mean ± SD = 9.9 ± 4.6; range from 2 to 20), and did not always correspond to them because of the presence of additional bands in antigen-specific immunoblotting that were not visible in IEF.

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094