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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Epstein-Barr virus-specific intrathecal oligoclonal IgG production in relapsing-remitting multiple sclerosis is limited to a subset of patients and is composed of low-affinity antibodies

Figure 3

Affinity ratio distributions. Affinity ratio (AR) values of anti-Epstein Barr nuclear antigen 1 (EBNA-1) IgG and of anti-viral capsid antigen (VCA) IgG in cerebrospinal fluid (CSF) and serum from 50 relapsing-remitting multiple sclerosis (RRMS), 50 other inflammatory neurological disease (OIND) and 50 noninflammatory neurological disease (NIND) patients. Anti-EBNA-1 IgG and anti-VCA IgG CSF AR values were significantly higher in RRMS and OIND than in NIND (panels A and B; Mann- Whitney with Bonferroni correction; P <0.0001), without any further statistical differences between RRMS and controls for anti-EBNA-1 IgG and anti-VCA IgG serum AR values (panels C and D). Each point represents a single observation, excluding outliers. Horizontal bars indicate medians and error bars correspond to the standard error.

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