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Table 3 Frequency of cerebrospinal fluid (CSF) and serum samples with detectable levels of anti-Epstein Barr nuclear antigen 1 (EBNA-1) and anti-viral capsid antigen (VCA) IgG in patients with relapsing-remitting multiple sclerosis (RRMS), other inflammatory neurological disorders (OIND) and noninflammatory neurological disorders (NIND)

From: Epstein-Barr virus-specific intrathecal oligoclonal IgG production in relapsing-remitting multiple sclerosis is limited to a subset of patients and is composed of low-affinity antibodies

 

Anti-EBNA-1 IgG

Anti-VCA IgG

 

CSF

Serum

CSF

Serum

RRMS (n = 100)

96/100 (96%)a

99/100 (99%)

65/100 (65%)

90/100 (90%)

OIND (n = 100)

91/100 (91%)

96/100 (96%)

86/100 (86%)b

94/100 (94%)

NIND (n = 100)

86/100 (86%)

94/100 (94%)

74/100 (74%)

90/100 (90%)

  1. CSF anti-EBNA-1 IgG (Chi-square with Bonferroni correction): aRRMS versus NIND (P <0.05); CSF anti-VCA IgG (Chi-square with Bonferroni correction): bOIND versus RRMS (P <0.001).