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Table 5 Correlations between cerebrospinal fluid (CSF) and serum levels of anti-Epstein Barr nuclear antigen 1 (EBNA-1) and anti-viral capsid antigen (VCA) IgG and disease severity and duration in 100 patients with relapsing-remitting multiple sclerosis (RRMS)

From: Epstein-Barr virus-specific intrathecal oligoclonal IgG production in relapsing-remitting multiple sclerosis is limited to a subset of patients and is composed of low-affinity antibodies

 

EDSS

Disease duration (months)

CSF anti-EBNA-1 IgG levels (AU)

r = -0.1642

r = 0.1181

CSF anti-VCA IgG levels (AU)

r = 0.2294

r = 0.1184

Serum anti-EBNA-1 IgG levels (AU)

r = -0.336*

r = 0.0963

Serum anti-VCA IgG levels (AU)

r = 0.1901

r = 0.1443

  1. *Spearman: P <0.001.
  2. AU, arbitrary units; EDSS Expanded Disability Status Scale.