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Table 7 Cerebrospinal fluid (CSF) and serum distributions of high-affinity anti-Epstein Barr nuclear antigen 1 (EBNA-1) and anti-viral capsid antigen (VCA) IgG in a subgroup of relapsing-remitting multiple sclerosis (RRMS), other inflammatory neurological disease (OIND) and noninflammatory neurological disease (NIND) patients

From: Epstein-Barr virus-specific intrathecal oligoclonal IgG production in relapsing-remitting multiple sclerosis is limited to a subset of patients and is composed of low-affinity antibodies

 

RRMS

OIND

NIND

(n = 50)

(n = 50)

(n = 50)

CSF anti-EBNA-1 IgG: RA4 >2.5, n/total (%)

48/50 (96%)a

45/50 (90%)

40/50 (80%)

CSF anti-VCA IgG: RA4 >2.5, n/total (%)

48/50 (96%)b

47/50 (94%)c

40/50 (80%)

Serum anti-EBNA-1 IgG: RA4 >2.5, n/total (%)

47/50 (94%)

47/50 (94%)

48/50 (96%)

Serum anti-VCA IgG: RA4 >2.5, n/total (%)

44/50 (88%)d

40/50 (80%)

32/50 (64%)

  1. CSF anti-EBNA-1, RA4 >2.5 (Chi-square with Bonferroni correction): aRRMS versus NIND (P <0.05); CSF anti-VCA, RA4 >2.5 (Chi-square with Bonferroni correction): bRRMS versus NIND (P <0.05) and cOIND versus NIND (P <0.05); serum anti-VCA: RA4 >2.5 (Chi-square with Bonferroni correction): dMS versus NIND (P <0.01). NIND noninflammatory neurological disorders; OIND, other inflammatory neurological disorders; RA4, percentage of IgG remaining after treatment with 5 M NaSCN; RRMS, relapsing-remitting multiple sclerosis.
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Journal of Neuroinflammation

ISSN: 1742-2094