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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Exacerbation of blast-induced ocular trauma by an immune response

Figure 3

Cell death affects each layer of the cornea and is necroptotic. (A, C, E) Epifluorescence micrographs of TUNEL (red) and DAPI (blue). (B, D, F) Epifluorescence micrographs of RIP1 (green), RIP3 (red), and DAPI (blue). (A) In control corneas, TUNEL is rare and restricted to the epithelium (epi). (B) The control cornea is negative for both RIP1 and RIP3. (C) At three days post-blast wave exposure TUNEL is increased in the epi and is present in the stroma. (D) The cornea is still negative for RIP1 and RIP3 at three days post-injury. (E) At 28 days post-blast wave exposure, all three layers of the cornea are positive for TUNEL. (F) Both RIP1 and RIP3 are present in the epi, as well some light labeling in the endothelium (endo) and stroma. The scale bar in (A) is 50 μm and applies to all of the images in Figure 3.

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