The effect of thrombin-cleaved osteopontin and recombinant mouse osteopontin on preterm brain injury. Bar graphs show the total tissue volume loss (%) in the gray matter (A, C and E) and white matter (B, D and F) of mice given intranasal thrombin-cleaved osteopontin (T-OPN) (A and B), intranasal recombinant mouse OPN (rmOPN) (C and D) and intracerebroventricular (ICV) rmOPN (E and F) at 7 days after hypoxia-ischemia (HI)-induced injury. Intranasal administration: vehicle (Veh), n = 20; T-OPN, n = 14; rmOPN, n = 17. ICV administration: vehicle (Veh), n = 31; rmOPN, n = 27. Data presented are the mean ± SD.