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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Quinolinic acid toxicity on oligodendroglial cells: relevance for multiple sclerosis and therapeutic strategies

Figure 1

Characterization of the kynurenine pathway (KP) in N19 (a-e) and N20.1 (e-h) oligodendroglial cell lines. Levels of TDO-2 transcripts in (a) N19 and (e) N20.1 cells in differentiated state, with or without IFN-γ treatment. N19 cells (b) and N20.1 cells (f) showed positive TDO-2 cytoplasmic staining after 24 hours IFN-γ treatment. KP metabolic profile of oligodendroglial cell lines K/T ratio in N19 (c) and N20.1 (g) and kynurenic acid (KYNA), picolinic acid (PIC) and quinolinic acid (QUIN) profiles of N19 (d) and N20.1 (h) treated with or without IFN-γ. TDO-2, tryptophan 2,3-dioxygenase; K/T ratio, kynurenine and tryptophan ratio as a measure of IDO-1/TDO-2 activity; KYNA, kynurenic acid; PIC, picolinic acid; QUIN, quinolinic acid. Values are expressed as mean ± SE. ***P < 0.001, **P < 0.01 and *P < 0.05. Student's t-test.

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