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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Retinal antigen-specific regulatory T cells protect against spontaneous and induced autoimmunity and require local dendritic cells

Figure 2

New, peripherally generated beta-galactosidase (βgal)-specific regulatory T cells (Tregs) inhibit delayed-type hypersensitivity (DTH). (A) Ear swelling assay showing that retinal βgal is required to generate βgal-specific Tregs that can modulate the DTH response to βgal. Mice were analyzed 80 days post-transfer of 5 x 104 CD4+GFP cells from FG-BG2 mice. (B) Ear swelling assay showing that the presence of the retina is not necessary for maintaining βgal-specific Tregs. Mice were enucleated and compared to non-enucleated mice 4 months post-enucleation. Ear swelling measured at indicated time post-βgal injection. Results are given as mean ± SD with P values determined by t test.

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