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Figure 4 | Journal of Neuroinflammation

Figure 4

From: CaMKII inhibition with KN93 attenuates endothelin and serotonin receptor-mediated vasoconstriction and prevents subarachnoid hemorrhage-induced deficits in sensorimotor function

Figure 4

Cerebrovascular contractile responses to ET-1 at 72 h post-SAH. Concentration-response curves were elicited by the cumulative application of ET-1 to (A) MCA and (B) basilar arteries. In both arteries, the first phase of the concentration-response curve represents ET-1-induced contraction via ETB receptors and the second phase contraction mediated by ETA receptors. Previous studies have characterized these responses in detail [4],[9],[28]. Values are expressed as percentage of the K+-induced contraction and are presented as mean ± SEM. ***P <0.001. Number of animals in each group, n = 6–8.

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Journal of Neuroinflammation

ISSN: 1742-2094