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Table 1 The development and severity of animals with spontaneous recurrent seizures (SRS) during the 4-week video monitoring in experimental groups

From: Inhibition of the NLRP3 inflammasome provides neuroprotection in rats following amygdala kindling-induced status epilepticus

(A) Results from rats after 6 weeks of treatment with NLRP3 siRNA or control siRNA
  The number of rats developing SRS The time to development of SRS (days) The mean number of seizures (seizures/day) The mean seizure duration (sec/seizure)
Control siRNA + sham 0 (18) 0 0 0
NLRP3 siRNA+ sham 0 (18) 0 0 0
Control siRNA + SE 18 (18) 14.8 ± 5.5 7.58 ± 1.09 26.62 ± 6.94
NLRP3 siRNA+ SE 12 (18)a 27.5 ± 9.3a 1.34 ± 0.44a 10.48 ± 2.76a
(B) Results from rats after 6 weeks of treatment with caspase-1 siRNA or control siRNA
  The number of rats developing SRS The time to development of SRS (days) The mean number of seizures (seizures/day) The mean seizure duration (sec/seizure)
Control siRNA + sham 0 (18) 0 0 0
Caspase-1 siRNA + sham 0 (18) 0 0 0
Control siRNA+ SE 17 (18) 16.6 ± 6.1 9.02 ± 1.56 23.67 ± 5.90
Caspase-1 siRNA+ SE 11 (18)a 26.8 ± 9.1a 2.40 ± 0.78a 8.21 ± 2.66a
  1. All data are shown as mean ± standard deviation (n = 18 per group). a P < 0.05 versus control siRNA treatment.