Figure 6
Up-regulation of tumor necrosis factor receptor 1 (TNFR1) expression in microglia, endothelial cells, neurons, and oligodendrocyte progenitors after lipopolysaccharide (LPS)-sensitized hypoxic-ischemia (HI). Immunofluorescence of the LPS + HI group 24 hours post-insult showed up-regulated TNFR1 expression in Iba1-positive microglia, IB4-positive microvascular endothelial cells, NeuN-positive neurons, and O4-positive oligodendrocyte progenitors. TNFR1 also co-localized with p-JNK. Scale bar = 25 μm for NeuN and O4, and 50 μm for others. Inset scale bar = 5 μm.