Chlamydia pneumoniae infection of monocytes in vitro stimulates innate and adaptive immune responses relevant to those in Alzheimer’s disease

Table 1 Innate and adaptive immunity gene transcripts increased at 48 hours in Chlamydia pneumoniae (Cpn)-infected THP1 cells

	Gene symbol	Gene name
Inflammatory response	IL1F5	Interleukin 1 family, member 5 (delta)
	IL1F8	Interleukin 1 family, member 8 (eta)
	IL1RN	Interleukin 1 receptor antagonist
	IRAK2	Interleukin 1 receptor associated kinase 2
	NLRC4	NLR family, CARD domain containing 4
	TLR8	Toll-like receptor 8
	TNF	Tumor necrosis factor (TNF superfamily, member 2)
Host defense against bacteria	DEFB4	Defensin, beta 4
	DMBT1	Deleted in malignant brain tumors 1
	NFKBIA	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
	PTAFR	Platelet-activating factor receptor
Antibacterial response	COLEC12	Collection sub-family member 12
Antibacterial response	CYBB	Cytochrome B-245, beta polypeptide
Cytokines, chemokines, and their receptors	CCL2	Chemokine (C-C motif) ligand 2
	IFNB1	Interferon, beta 1, fibroblast
	IL6	Interleukin 6 (Interferon, beta 2)
Septic shock	SERPINA1	Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

Transcripts analyzed included those associated with the host response to pathogens, including inflammatory response genes, antibacterial humoral response genes, cytokines, chemokines and their receptors, genes involved in bacterial host defense mechanisms and septic shock.

ISSN: 1742-2094