Figure 1

Photographs of central and peripheral retina in C57BL/6N (rd8/rd8) and C57BL/6 J (wild-type) mice. A change in the distribution of fundus spots on B6-mice due to both age and the presence of the rd8 mutation is seen. Yellow spots are shown in central (A, C, E, and G) and peripheral (B, D, F, and H) fundus photographs of representative young (A-D) and old (E-H) B6-mice. Mice 2 to 8 months of age were classified as ‘young’, while mice 14 to 20 months of age were classified as ‘old’. Note that the number of central fundus spots is increased in old age for both rd8 mutant (G versus C) and wild-type (WT) (E versus A) mice. Furthermore, rd8/rd8 mice show a marked increase in central spots compared to WT, both in the young (C versus A) and old (G versus E) age groups.