Figure 7

Electron microscopy of retinal sections in old rd8/rd8 mice. Cells consistent with microglia/macrophages (MG/MΦ) were seen between the retinal pigment epithelium (RPE) and the photoreceptor outer segments (A,B). Higher magnification images from these cells (C,D) demonstrate the presence of photoreceptor outer segment debris (labeled with ^), occasional melanosomes, lipofuscin granules (*), and multiple phagosomes with partially degraded debris (#). The photoreceptor outer segments seen over the microglia in A and B are labeled as ROS (rod outer segments).