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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Activation of toll like receptor 4 attenuates GABA synthesis and postsynaptic GABA receptor activities in the spinal dorsal horn via releasing interleukin-1 beta

Figure 3

Lipopolysaccharide (LPS) suppresses GABAergic currents via activating protein kinase C (PKC). (A) shows recordings of GABAergic currents evoked by gamma-amino butyric acid (GABA) (100 μM) injected onto the recorded neuron at baseline, during and washout of the PKC activator (PMA, 2 μM). (B) shows recordings of GABA currents evoked by GABA (100 μM) injected onto a neuron recorded with a recording pipette filled with the intracellular solution containing the PKC inhibitor (PKCI 19–30, 5 μM) at before (baseline), and during perfusion of LPS (1 μg/ml). The mean (+SE) amplitudes of GABAergic currents and charge transfers at baseline, during and after washout of each tested agent are shown in bar graphs. Number of neurons included for the analysis is shown in each bar. **P < 0.01; ***P < 0.001; NS: no statistical significance.

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