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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Activation of toll like receptor 4 attenuates GABA synthesis and postsynaptic GABA receptor activities in the spinal dorsal horn via releasing interleukin-1 beta

Figure 5

The lipopolysaccharide (LPS)-induced suppression of gamma-amino butyric acid (GABA) synaptic activities is not ascribed to the reduced release probability of GABA from presynaptic terminals. The raw data show two GABAergic inhibitory postsynaptic currents (IPSCs) evoked by paired pulse electrical stimuli (100 ms apart) before, during and after washout of LPS (1 μg/ml). The recordings were made with a recording pipette filled with the intracellular solution containing the protein kinase C (PKC) inhibitor (PKCI 19-–30, 5 μM). Bar graphs show mean (+SE) amplitudes of P1, P2 and P2/P1 ratios at baseline, during and after washout of LPS (1 μg/ml). ***P < 0.001; NS: no statistical significance.

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