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Figure 8 | Journal of Neuroinflammation

Figure 8

From: Activation of toll like receptor 4 attenuates GABA synthesis and postsynaptic GABA receptor activities in the spinal dorsal horn via releasing interleukin-1 beta

Figure 8

Exogenous glutamine prevents the reduction induced by lipopolysaccharide (LPS) in GABAergic miniature inhibitory postsynaptic currents (mIPSCs). (A) shows GABAergic mIPSCs in the presence of glutamine (1 mM): amplitudes and frequencies of mIPSCs were not changed by bath-application of LPS (1 μg/ml). The recordings were made with a recording pipette filled with the intracellular solution containing the protein kinase C (PKC) inhibitor (PKCI 19–30, 5 μM). (B) Bar graphs show that mean (+SE) amplitudes and frequencies of mIPSCs in the presence of glutamine (1 mM) were not significantly altered by LPS. NS: no statistical significance.

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