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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Chemokine-mediated inflammation in the degenerating retina is coordinated by Müller cells, activated microglia, and retinal pigment epithelium

Figure 6

In situ hybridization for Cxcl10 mRNA in the retina following exposure to 24 hours of light damage. A: Expression of Cxcl10 was not apparent in dim-reared sections. B-C: Sections from the superior retina (B) showed stain for Cxcl10 mRNA in putative retinal pigment epithelium (RPE) cells (arrowheads) following 24 hrs light damage (LD), while no staining was observed in the inferior retina (D). D-E: Following 24 hrs of LD, stain for Cxcl10 mRNA appeared in the INL within superior retina (D-E; arrowheads). F: Staining for Cxcl10 was not readily apparent in the inferior retina. G-I: Sections with labeling for Cxcl10 mRNA (red; arrowheads) in the INL, which correlated with Müller cells immunolabeled with vimentin (green; arrowheads). J-K: Putative RPE cells, which were positive for Cxcl10 mRNA labeling (red; arrowheads), were also immunoreactive for the marker RPE65 (green; arrowheads). C, choroid; INL, inner nuclear layer; IHC, immunohistochemistry; ISH, in situ hybridization ONL, outer nuclear layer; OS, outer segments.

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