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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia

Figure 1

Scutellarin reduced NF κ B expression in activated microglia in vivo and in vitro . Confocal images showing the expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) (red) in lectin + microglia (green, arrows) in the penumbral zones of MCAO rat (D-F) and following scutellarin treatment (G-I). A drastic increase in the expression of NFκB (E) is evident in the activated microglia (D) in middle cerebral artery occlusion (MCAO) rat. Note that NFκB expression (H) is reduced in activated microglia (G) 7 days following treatment of MCAO rats with scutellarin. An upregulation of NFκB (N) is observed in lipopolysaccharide (LPS)-activated BV-2 microglia (M) in comparison to control (J-L). NFκB is reduced (Q) in activated microglia treated with scutellarin. DAPI - blue. Scale bars in A-I: 20 μm, J-R: 50 μm.

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Journal of Neuroinflammation

ISSN: 1742-2094