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Figure 8 | Journal of Neuroinflammation

Figure 8

From: Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia

Figure 8

Scutellarin reduced MCP-1 expression in activated microglia after middle cerebral artery occlusion (MCAO). Confocal images showing the expression of monocyte chemoattractant protein-1 (MCP-1) (red) in lectin + microglia (green) in the penumbral zones of MCAO rat (D-F) and following treatment with Scutellarin (G-I). Increase in MCP-1 expression (E) can be observed in the activated microglia (D) in MCAO rat. A marked reduction of MCP-1 expression (H) is observed in activated microglia (G) 7 days following treatment with scutellarin. DAPI - blue. Scale bars in A-I: 20 μm. The expression levels of MCP-1 in MCAO rat are depressed significantly at 3 and 7 days (J) following treatment with scutellarin at low (SL) and high (SH) dosage when compared with the MCAO rats not treated with the drug (compared with M). Significant differences in protein levels between MCAO and drug used rats are expressed as * P <0.01.

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