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Figure 9 | Journal of Neuroinflammation

Figure 9

From: Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia

Figure 9

MCP-1 expression was suppressed following treatment of lipopolysaccharide (LPS)-activated BV-2 microglia with scutellarin. Confocal images show an upregulation of Monocyte chemoattractant protein-1 (MCP-1) (E) in LPS-activated BV-2 microglia (D) in comparison to control (A-C). Pretreatment with scutellarin leads to decrease in the expression of MCP-1 (H) in LPS-activated BV-2 microglia (G). DAPI - blue. Scale bars in A-I: 50 μm. The expression levels of MCP-1 in LPS-activated BV-2 microglial cells are depressed significantly following treatment with scutellarin by western blot (J, K). Significant difference in protein level between LPS and scutellarin-treated cells are expressed as * P <0.01. The values represent the mean ± SD in triplicate.

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Journal of Neuroinflammation

ISSN: 1742-2094