Figure 3

Lack of PTX3 impairs angiogenesis 14 days after middle cerebral artery occlusion (MCAo). Proliferating vessels (indicated by white arrows in (A) and (D)) are seen in the striatum 6 days (A) and 14 days (D) after MCAo. Angiogenesis is similar for both genotypes 6 days after MCAo (B), but PTX3 knockout (KO) have less striatal proliferating vessels than wild-type (WT) mice 14 days after MCAo (E), even after normalisation with the total amount of PECAM-1 (E) and (F). Scale bars = 50 μm. Students t-test (n = 4) was used. *P <0.05. Error bars show SEM.