Figure 1
From: Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism
Effect of in-vivo intranigral injection of neuromelanin on microglia population. Microglia population was evaluated in terms of Iba1 (A,D) and CD16/32 (B,E) in sham (A-C) and neuromelanin-injected animals (D-F). Inserts in C and F are high-magnification photographs of each condition. Note the typical morphological features of activated microglia in response to neuromelanin injections in terms of Iba1 (D) and upregulation of CD16/32 (E). The dashed line in D-F shows the presence of insoluble neuromelanin within the ventral mesencephalon. Scale bar, 100 μm.